Purpose: Primary malignant musculosqueletal tumors in adult
are rare affections group and its treatment is still a real challenge today.
The aim of this work was to describe the epidemiologic and treatment aspects of
these tumors in the national reference center of our country. Materiel and Methods: It was a
retrospective review of primary malignant musculosqueletal tumors treated in
orthopedics and trauma unit of Sylvanus Olympio teaching hospital of Lomé, Togo
from January 2000 to December 2014. Results: During the
study period, 28 cases were selected and reviewed. There were 17 men (60.71%)
and 11 women (39.29%). The average age was 32.7 years. There were 20 cases
(71%) of primary malignant bone tumors (PMBT) and 8 cases (29%) of primary
malignant soft tissues tumors (PMSTT). There were 6
(30%) of osteosarcoma. The tumor was located in the bones of the forearm and wrist/hand in 2 (10%) patients for each
anatomical site; for the lower limb, around knee in 7 (35%) patients. Eight
patients had PMSTT (28, 57%). There were three cases of rhabdomyosarcoma, 2
cases of fibrosarcoma. Tumors were located around knee in 4 cases and around
ankle/foot in 3 cases. In the two groups of tumor, tumor resection was performed in 5 patients (17.86%) and limb amputation
indicated in 23 patients (82.14%), was performed in 15 (53.57%) and 8 patients
(37.78%), rejected it and left hospital against medical advice. Conclusion: Malignant musculoskeletal
tumors are relatively rare in Togo. Their treatment is based on radical surgery
which is often not supervised by adjuvant therapies. Ignorance, poverty of the
population and embryonic state of diagnostic and treatment infrastructures are
the obstacles to their care. Education and awareness must be integrated to care
and fight against this group of diseases.
References
[1]
Bergovec, M., Kubat, O., Smerdelj, M., Seiwerth, S., Bonevski, A. and Orlic, D. (2015) Epidemiology of Musculoskeletal Tumors in a National Referral Orthopedic Department. A Study of 3482 Cases. Cancer Epidemiology, 18 February, pii: S1877-7821(15)00035-1.
[2]
Schwab, J.H., Lozano-Calderon, S.A., Mankin, H.J., Raskin, K.A. and Hornicek, F.J. (2014) What’s New in Primary Bone Tumors. Journal of Bone & Joint Surgery, 96, 2099-2104.
[3]
Solooki, S., Vosoughi, A.R. and Masoomi, V. (2011) Epidemiology of Musculoskeletal Tumors in Shiraz, South of Iran. Indian Journal of Medical and Paediatric Oncology, 32, 187-191.
[4]
Dabak, N., Cirakl, A., Gülman, B., Selcuk, M.B. and Baris, S. (2014) Distribution and Evaluation of Bone and Soft Tissue Tumors in the Middle Black Sea Region. Acta Orthopaedica et Traumatologica Turcica, 48, 17-24. http://dx.doi.org/10.3944/AOTT.2014.3013
[5]
Eyesan, S.U., Obalum, D.C., Nnodu, O.E., Abdulkareem, F.B. and Ladejobi, A.O. (2009) Challenges in the Diagnosis and Management of Musculoskeletal Tumours in Nigeria. International Orthopaedics, 33, 211-213.
[6]
Eyesan, S.U., Obalum, D.C., Onovo, D.O., Ketiku, K.K. and Abdulkareem, F.B. (2009) Indications for Ablative Surgery in Extremity Musculoskeletal Tumours. Nigerian Quarterly Journal of Hospital Medicine, 19, 206-209.
[7]
Kouame, M., Yepie, A., Traore, M., Anoumou, M., Gogoua, R., Kone, B. and Varango, G. (2015) Tumeurs osseuses des membres: Les écueils de la prise en charge dans notre contexte. Livre des résumé 11ème congrès de la Société Africaine d’Orthopédie (SAFO), p 52.
[8]
Walla, A., James, Y.E., Amakoutou, K., Abalo, A., Dossim, A.M., Gnandi-Pio, F. and Ayouba, G. (2015) Les tumeurs osseuses primitives des membres au CHU Tokoin de Lomé. European Scientific Journal, 11, 149-157.
[9]
Darré, T., Amégbor, T., Blitti, C.M., Saka, B., Mouhari-Touré, A., Sonhaye, L., Bissa, H., Pegdessou, E., Sewa, E. and Napo-Koura, G. (2013) Profil histo-épidémiologique des sarcomes des tissus mous au Togo. Carcinologie Clinique en Afrique, 12, 11-15.
[10]
Koffi, A., Tchin, D., Lantam, S., Faré, G.P. and Napo-Koura, G. (2009) Aspects épidémiologiques et histopathologiques de 178 cas de cancers primitifs observés au CHU de Lomé. Revue Africaine de Pathologie, 8, 3-7.
[11]
Abbas, J.S., Holyoke, E.D., Moore, R. and Karakousis, L.P. (1981) The Surgical Treatment and Outcome of Soft Tissue Sarcoma. Archives of Surgery, 116, 765. http://dx.doi.org/10.1001/archsurg.1981.01380180025006
[12]
Grimer, R.J., Carter, S.R., Tillman, R.M., et al. (1999) Endoprosthetic Replacement of the Proximal Tibia. Journal of Bone and Joint Surgery, 81, 488-494. http://dx.doi.org/10.1302/0301-620X.81B3.9234
[13]
Shalaby, S., Shalaby, H. and Bassiony, A. (2006) Limb Salvage for Osteosarcoma of the Distal Tibia with Resection Arthrodesis, Autogenous Fibular Graft and Ilizarov External Fixator. Journal of Bone and Joint Surgery, 88, 1642-1646. http://dx.doi.org/10.1302/0301-620X.88B12.17879
[14]
Ogura, K., Miyamoto, S., Sakuraba, M., Fujiwara, T., Chuman, H. and Kawai, A. (2015) Intercalary Reconstruction after Wide Resection of Malignant Bone Tumors of the Lower Extremity Using a Composite Graft with a Devitalized Autograft and a Vascularized Fibula. Sarcoma, 2015, Article ID: 861575. http://dx.doi.org/10.1155/2015/861575
[15]
Schwab, J.H., Springfield, D.S., Raskin, K.A., Mankin, H.J. and Hornicek, F.J. (2013) What’s New in Primary Malignant Musculoskeletal Tumors. Journal of Bone and Joint Surgery, 18, 2240-2246.
[16]
Chan, W.P. (2013) Magnetic Resonance Imaging of Soft-Tissue Tumors of the Extremities: A Practical Approach. World Journal of Radiology, 28, 455-459.
[17]
Fletcher, C.D., Unni, K.K., Mertens, F., et al. (2002) WHO Classification of Tumors: Pathology and Genetics in Tumors of Soft Tissue and Bone. IARC Press, Lyon.