Background: Cutaneous metastasis of ovarian
epithelial adenocarcinoma is rare, and most cases present as cutaneous nodules, generally as periumbilical Sister Joseph’s nodules. An uncommon presentation of
cutaneous metastases from ovarian carcinoma is perineal tumor. Case: A
56-year-old patient has a serous adenocarcinoma reveled with a perineal tumor.
After surgery, the patient started chemotherapy with bad evolution, and the patient died after 3 months. Conclusions: The prognosis of the
cutaneous metastasis of the ovarian adenocarcinoma is poor, but palliative
treatment is usually indicated that further studies evaluating the role of specific therapies are needed to guide treatment.
References
[1]
Howlader, N., Noone, A.M.,
Krapcho, M., Neyman, N., Aminou, R., Waldron, W., Altekruse, S.F., Kosary, C.L.,
Ruhl, J., Tatalovich, Z., Cho, H., Mariotto, A., Eisner, M.P., Lewis, D.R.,
Chen, H.S., Feuer, E.J., Cronin, K.A. and
Edwards, B.K.,
Eds. (2011) SEER
Cancer Statistics Review, 1975-2008. National Cancer Institute, Bethesda, MD. Based
on November 2010 SEER Data Submission, Posted to the SEER Web Site. http://seer.cancer.gov/csr/1975_2008/
Hardy, J.R.
and
Harvey, V.J. (1989)
Cerebral
Metastases in Patients with Ovarian Cancer Treated with Chemotherapy. Gynecologic Oncology, 33, 296-300. http://dx.doi.org/10.1016/0090-8258(89)90515-5
[4]
Siegel, R., Naishadham, D. and Jemal, A. (2012)
Cancer Statistics, 2012. CA:A Cancer Journal
for Clinicians, 62,
10-29. http://dx.doi.org/10.3322/caac.20138
Cormio, G., Capotorto,
M., Di
Vagno, G., Cazzolla,
A., Carriero,
C. and
Selvaggi, L.
(2003)
Skin Metastases in Ovarian Carcinoma: A Report of Nine Cases and a Review
of the Literature. Gynecologic Oncology, 90,
682-685. http://dx.doi.org/10.1016/S0090-8258(03)00400-1
[7]
White, J.W., Spencer, P.S. and
Helm, T.N. (1987)
Skin
Metastases in Cancer Patients. Cutis, 39, 119-121.
[8]
Krumerman, M.
and
Garret, R.
(1977)
Carcinoma
Metastatic to Skin. New York State
Journal of Medicine, 77, 1900-1903.
Tourad, J.P., Lentz, N.,
Dutronc, Y., Mercier, E., Sagot, P. and
Lambert, D. (2000) Umbilical
Cutaneous Metastasis (or Sister Mary Joseph’s Nodule) Disclosing an Ovarian
Adenocarcinoma. Gynécologie Obstétrique
& Fertilité, 28,
719-721.
[11]
Merimsky, O.,
Chaitchik, S.
and
Inbar, M.
(1991)
Skin
Metastases of Ovarian Cancer: Report of Three Cases. Tumori, 77, 268-270.
[12]
Traiman, P., De
Luca, L.A. and
Bacchi, C.B. (1994)
An Extremely
Large, Cauliflower Type, Cutaneous Metastases of Ovarian Cancer Associated with Good Prognosis. Gynecologic Oncology, 53, 239-241. http://dx.doi.org/10.1006/gyno.1994.1122
[13]
Schonmann,
R., Altaras, M., Biron,
T., Bernheim,
J. and
Fishman, A.
(2003) Inflammatory
Skin Metastases from Ovarian Carcinoma—A Case Report and Review of the Literature. Gynecologic Oncology, 90,
670-672. http://dx.doi.org/10.1016/S0090-8258(03)00366-4
[14]
Sartori,
E., Chiudinelli, F., Pasinetti, B., Sostegni, B. and Maggino, T. (2010) Possible
Role of Palliative
Surgery for Bowel Obstruction in Advanced Ovarian Cancer Patients. European Journal of Gynaecological Oncology, 21,
31-36.
[15]
Demirci, S., Yavas, F., Ozsaran, Z., Ozsaran, A., Dikmen, Y.,
Zekioglu, O., Karabulut, B. and Aras,
A.B. (2010)
Palliative Radiotherapy for the Skin Metastasis of Ovarian Cancer: A Case Report
and Review of the Literature. Medical
Oncology, 27,
628-631. http://dx.doi.org/10.1007/s12032-009-9259-z
[16]
Stanley,
M.A. (2002)
Imiquimod and the Imidazoquinolones: Mechanism of Action and Therapeutic
Potential. Clinical and Experimental
Dermatology, 27,
571-577. http://dx.doi.org/10.1046/j.1365-2230.2002.01151.x
[17]
Craig,
C.D., Iglesias, D.A., Watkins, J., Coleman, R.L., Kilgore,
L.
and Ramirez, P.T.
(2013) Extensive
Cutaneous Metastases of Ovarian Cancer after Prolonged Response to Liposomal Doxorubicin. Gynecologic Oncology Reports, 5, 64-66. http://dx.doi.org/10.1016/j.gynor.2013.05.005
[18]
Campana,
L.G., Valpione, S., Falci, C., et al.
(2012) The
Activity and Safety of Electrochemotherapy in Persistent Chest Wall
Recurrence from Breast Cancer after Mastectomy: A Phase-II Study. Breast Cancer Research and Treatment, 134,
1169-1178. http://dx.doi.org/10.1007/s10549-012-2095-4
