β-环糊精/羟基磷灰石的制备与性能研究
Study on Preparation and Characterization of β-Cyclodextrin/Hydroxyapatite

DOI: 10.12677/HJCET.2016.61001, PP. 1-6

Keywords: 羟基磷灰石，β-环糊精，棒状，作用机理
Hydroxyapatite, β-Cyclodextrin, Rodlike Structures, Reaction Mechanism

Full-Text   Cite this paper   Add to My Lib

Abstract:

本研究分别以CaCl₂和H₃PO₄为钙源和磷源，NaOH为pH调节剂，成功制备了β-环糊精(β-CD)/羟基磷灰石(HAP)复合物。借助傅里叶变换红外光谱(FT-IR)、热重分析(TG)和扫描电镜(SEM)对反应产物进行了表征，研究β-CD浓度对产物的组成、热稳定性、形貌等的影响。结果表明，β-CD可以影响产物组成和形貌，随着β-CD浓度的增大，产物由最初的无规团聚逐渐变成针状、棒状结构。结合β-CD的分子结构及其自组装性能，对β-CD与HAP的反应机理进行了初步探讨。
β-cyclodextrin/hydroxyapatite was prepared by using calcium chloride (CaCl₂) and phosphate (H₃PO₄) as the resource of calcium and phosphorus, respectively. During the synthesis, NaOH was used as pH adjusting agent to control the pH of the solution. Fourier transform infrared spectros-cope (FT-IR), thermogravimetric analysis (TG) and scanning electron microscopy (SEM) were used to characterize the product. The effects of the concentration of β-cyclodextrin on the size, compo-sition and morphology of the product were investigated. The results showed that β-cyclodextrin could significantly influence the composition and morphology of the product. With the increasing of β-cyclodextrin concentration, the structure of the product grew from the initial random aggregation to needle-like and rodlike structures. The reaction mechanism between β-CD and HAP was discussed on the basis of the special molecular structure of β-CD and its self-assemble property.

References

[1]	Fathi, M.H. and Hanfi, A. (2007) Evaluation and Characterization of Nanostructure Hydroxyapatite Powder Prepared by Simple Sol-Gel Method. Materials Letters, 61, 3978-3983. http://dx.doi.org/10.1016/j.matlet.2007.01.028
[2]	王宏伟, 贾延辉. 纳米羟基磷灰石的制备方法及应用[J]. 承德医学院学报, 2008, 25(3): 304-305.
[3]	赵珊, 李延报, 李东旭. 功能性羟基磷灰石生物复合材料的研究进展[J]. 材料导报: 综述篇, 2010, 24(8): 69-72.
[4]	陈佳正, 等. 骨组织材料制备研究[J]. 西南民族大学学报, 2010, 36(5): 787-790.
[5]	石和彬, 钟宏, 刘羽, 等. 共沉淀法制备纳米羟基磷灰石[J]. 化学与生物工程, 2012, 29(8): 16-20.
[6]	袁媛, 刘昌胜. 溶胶凝胶法制备纳米羟基磷灰石[J]. 中国医学科学院学报, 2002, 24(2): 129-133.
[7]	李亚东. 水热法制备羟基磷灰石研究进展[J]. 中国口腔种植学杂志, 2002, 7(4): 189-192.
[8]	朱丹琛, 肖秀峰, 等. 以环糊精为模板水热合成羟基磷灰石[J]. 人工晶体学报, 2010, 39(1): 214-220.
[9]	邱超凡, 肖秀峰, 等. β-环糊精为模板控制合成球状羟基磷灰石[J]. 人工晶体学报, 2007, 36(6): 1390-1402.
[10]	Martínez-Pérez, C.A. and García-Montelongo, J. (2012) Preparation of Hydroxyapatite Nanoparticles Facilitated by the Presence of β-Cyclodextrin. Journal of Alloys and Compounds, , 432-436.
[11]	Son, K.D. and Kim, Y.-J. (2013) Morphological Structure and Characteristics of Hydroxyapatite/β-Cyclodextrin Com- posite Nanoparticles Synthesized at Different Conditions. Materials Science and Engineering: C, 33, 499-506. http://dx.doi.org/10.1016/j.msec.2012.09.020
[12]	Yang, L., Zhang, X.Y., Liao, Z.J., Guo, Y.M., Hu, Z.G. and Cao, Y. (2003) Interfacial Molecular Recognition between Polysaccharides and Calciumcarbonate during Crystallization. Journal of Inorganic Biochemistry, 97, 377-383. http://dx.doi.org/10.1016/S0162-0134(03)00311-8
[13]	Jaiswal, S., Duffy, B., Jaiswal, A.K., Stobie, N. and McHale, P. (2010) Enhancement of the Antibacterial Properties of Silver Nanoparticles Using β-Cyclodextrin as a Capping Agent. International Journal of Antimicrobial Agents, 36, 280-283. http://dx.doi.org/10.1016/j.ijantimicag.2010.05.006
[14]	薛青芳. β-环糊精/纳米银的制备及对粘胶非织造布的抗菌整理[D]: [硕士学位论文]. 武汉: 武汉纺织大学, 2013: 26-28.
[15]	Cobos Cruz, L.A., Martinez Perez, C.A., Monreal Romero, H.A. and García Casillas, P.E. (2008) Synthesis of Magnetite Nanoparticles-β-Cyclodextrin Complex. Journal of Alloys and Compounds, 466, 330-334. http://dx.doi.org/10.1016/j.jallcom.2007.11.081
[16]	Wang, T., Dorner-Reisel, A. and Müller, E. (2004) Ther-mogravimetric and Thermokinetic Investigation of the Dehydroxylation of a Hydroxyapatite Powder. Journal of the European Ceramic Society, 24, 693-698. http://dx.doi.org/10.1016/S0955-2219(03)00248-6
[17]	孙晓红, 郑春明. β-环糊精作为超分子壳制备BaTiO3纳米晶体[J]. 无机化学学报, 2008, 24(1): 93-97.

Full-Text