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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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左归丸对卵巢切除所致骨质疏松大鼠骨钙素 和降钙素含量的影响
Keywords: Zuogui pill, osteoporosis, bone gla-containing protein (BGP), calcitonim (CT)
Abstract:
目的：探讨左归丸防治骨质疏松症的机理。方法：以卵巢切除所致的骨质疏松大鼠为模型,采用骨组织形态计量学方法测定胫骨骨小梁体积百分比(TBV%)、骨小梁吸收表面百分比(TRS%)和骨小梁形成表面百分比(TFS%),采用放射免疫分析法测定外周血清中雌二醇(E2)、骨钙素(BGP)和降钙素(CT)的含量。结果：左归丸能使胫骨TBV%显著增高,使TRS%和TFS%显著降低。大鼠切除卵巢后,在E2含量大幅度降低的同时,BGP含量明显增加,CT含量明显降低。左归丸对E2含量无显著影响,但能使CT含量增加,使BGP含量降低。结论：左归丸能使CT含量增加是其防治骨质疏松症的机理之一
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