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秀丽隐杆线虫在化学品毒性评估中的研究进展

Keywords: 秀丽隐杆线虫,化学品,毒性评估,模式生物

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Abstract:

?化学品毒性评估的传统经典方法是啮齿类动物毒性实验。随着世界各地新化学品的合成数量增多,传统的毒性检测评估模式和测试速度已经远远不能满足市场和人群的健康需求。模式生物秀丽隐杆线虫(caenorhabditis?elegans)因其独特的生物学优势正逐渐地被应用到化学品的毒性评估研究中。本文将从秀丽隐杆线虫的生物学优势、化学品毒性评估时线虫基因型的选择、染毒方式、评估指标、高通量筛选技术等方面进行综述,并简要介绍线虫毒性评估的研究专利。最后,对秀丽隐杆线虫的化学品毒性评估应用前景进行讨论和展望。

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