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bdnf/trkb信号途径与抗肿瘤治疗

Keywords: bdnf,trkb,肿瘤,耐药性,抗肿瘤治疗

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Abstract:

?肿瘤是目前危害人类健康的主要疾病之一。治疗肿瘤的主要手段包括手术、放疗、化疗和生物治疗等,但耐药现象的产生,导致药物治疗效果不甚理想。研究表明脑源性神经营养因子(bdnf)及其酪氨酸激酶爱体b(trkb)在肿瘤的发生发展中起着非常重要的作用,激活bdnf/trkb信号途径除了刺激肿瘤细胞存活,血管发生及失巢凋亡以外,还与肿瘤细胞的耐药性密切相关。本文主要综述bdnf/trkb信号途径对肿瘤耐药的影响及相应的抗肿瘤治疗应用,以期为克服肿瘤多药耐药性提供新的研究思路,从而进一步提高肿瘤患者生存率和改善预后。

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