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OALib Journal期刊
ISSN: 2333-9721
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kcnq4和gjb2基因多态性与职业噪声性听力损失的相关性研究
Keywords: kcnq4,gjb2,噪声性听力损失,基因多态性
Abstract:
？目的:探讨kcnq4和gjb2基因多态性与职业噪声性听力损失的相关性。方法:采用1:1配对病例对照研究,应用pcr和直接测序法,检测了103对噪声性听力损失工人与噪声暴露听力正常工人的kcnq4rs34287852和gjb2rs3751385位点的基因型,分析目的snp位点基因型与职业噪声性听力损失发生的关系。结果:kcnq4rs34287852位点t,g等位基因及各基因型在病例与对照组间的分布差异无统计学意义(p>0.05)。病例组gjb2rs3751385位点c等位基因的频率明显高于对照组(pp结论:gjb2rs3751385位点突变与噪声性听力损失存在相关性,gjb2rs3751385cc基因型可能是噪声性听力损失的易感基因型之一。
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