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三丁基锡对小鼠脾、肝和脑组织蛋白磷酸酶2a活性的影响

Keywords: 三丁基锡,蛋白磷酸酶2a,,,

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Abstract:

?目的:研究三丁基锡(tributyltin,tbt)对小鼠脾、肝和脑组织蛋白磷酸酶2a(proteinphosphatase2a,pp2a)活性的影响。方法:将不同浓度tbt(0、10、20、60mg/kg),分别以灌胃的方式对小鼠染毒24和96h,检测脾、肝和脑组织pp2a酶活性的改变。结果:tbt染毒24和96h,小鼠脾脏pp2a酶活性在20和60mg/kg剂量组明显下降,与对照组相比差异均具有统计学意义(p<0.01);肝脏pp2a酶活性仅在60mg/kg时,较对照组明显被抑制(p<0.05);而脑pp2a酶活性在各浓度组与对照组相比均未发生明显改变(p>0.05)。结论:pp2a酶活性的降低可能是tbt产生免疫和肝毒性效应的重要分子机制。

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