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精子发生过程中的组蛋白替换

Keywords: 精子,表观遗传学,乙酰化,组蛋白,鱼精蛋白

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Abstract:

?精子细胞在形态学上高度特化,其表观遗传学调控亦高度特化。组蛋白被鱼精蛋白替换为精子发生过程中独特的、非传统的表观遗传学调控方式。影响精子中组蛋白替换的主要因素有:组蛋白乙酰化修饰、组蛋白变体的影响、过渡蛋白tp1和tp2的作用、鱼精蛋白p1和p2的比值等。本文就精子发生过程中的组蛋白替换相关内容作简要综述。

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