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双核细胞中核质桥和核芽的形成及其影响因素

Keywords: 核质桥,核芽,电离辐射,染色体损伤,胞质分裂阻滞法,毒理基因组学

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Abstract:

?胞质分裂阻滞法(cytokinesis-blockmicronucleus,cbmn)主要用来分析双核细胞中的微核,研究发现该方法还可以分析其他指标,如核质桥和核芽等。目前核质桥(nucleoplasmicbridge,npb)及核芽(nuclearbud,nbd)分析是细胞组学分析的重要组成部分。npb和nbd的形成受到许多因素的影响,而且有望成为新的辐射损伤生物标志物。本文将对npb和nbd的定义、形态特征、形成机制及影响因素等方面进行综述。

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