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keap1-nrf2-are在机体氧化应激损伤中的防御作用

Keywords: nrf2,氧化应激,转录

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Abstract:

?氧化应激损伤与机体多种病理过程密切相关,如肿瘤、老年性神经退行性疾病等。核转录因子nrf2以keap1-nrf2-are信号通路介导并激活多种抗氧化基因和ii相解毒酶基因的转录,从而减轻ros和亲电子物质引起的细胞损伤,维持机体氧化-抗氧化的生理平衡。本文综述了keap1-nrf2-are介导抗氧化物对抗氧化应激损伤的作用和机制,为抗氧化药物机制的探讨奠定基础。

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