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OALib Journal期刊
ISSN: 2333-9721
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可降解镁合金表面载药涂层的制备和性能
Keywords: 有机高分子材料,药物洗脱支架,载药涂层,聚乳酸--聚三亚甲基碳酸酯共聚物
Abstract:
？在可降解az31b镁合金心血管支架表面成功制备了携带雷帕霉素的聚乳酸--聚三亚甲基碳酸酯(pla--ptmc)共聚物涂层,评价了涂层的表面形貌、降解性能、血液相容性和药物释放性能.结果表明,pla--ptmc共聚物作为载药涂层具有良好的柔韧性,表面均匀、光滑,降解周期超过1个月,血液相容性良好.涂层具有缓释雷帕霉素的功能,释药周期超过1个月,可在内膜增生期内有效抑制支架植入后再狭窄的发生,满足冠脉支架表面载药层的使用要求.
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