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OALib Journal期刊
ISSN: 2333-9721
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肝素和聚氨酯同溶液体系混合接枝及其抗凝血性
Keywords: 有机高分子材料,抗凝血性,接枝,肝素,聚氨酯
Abstract:
？利用全新的四氢呋喃和水的溶液体系将肝素与不溶于水的聚氨酯同溶液混合,制备出含有肝素的聚氨酯薄膜.利用碳二亚胺缩合反应将肝素接枝在聚氨酯分子上以改善材料的长效抗凝血性.在肝素过量的情况下,制备出同时含有游离和接枝肝素的聚氨酯薄膜,并初步评价了薄膜中肝素的扩散速率以及体外抗凝血性.结果表明,肝素均匀分布在薄膜中,肝素活性保持良好,扩散缓慢,具有相对长效的抗凝血活性.接枝后的肝素仍具有良好的生物活性,同时含有接枝和游离肝素薄膜的抗凝血性优异.
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