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OALib Journal期刊
ISSN: 2333-9721
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多级开孔壳聚糖海绵的细胞行为分析
Keywords: 有机高分子材料,壳聚糖,多级开孔支架,蜂窝状结构,细胞相容性
Abstract:
？使用冰滴为致孔剂制备表面大孔、内部孔洞相连的新型壳聚糖(hpcs)支架,将其与聚乳酸复合制备出三维蜂窝状孔洞结构的复合支架(thcp)。对hpcs和thcp进行了表面形貌、力学性能、细胞相容性等方面的表征,并与常规冻干法所制备的壳聚糖(cs)海绵进行了对比。结果表明,在hpcs海绵表面均匀分布着大而开放的孔洞,大孔内部形成相互贯通的小孔,在thcp复合海绵内部形成了相互贯通的蜂窝状结构。thcp支架的力学强度比纯壳聚糖支架有明显的提高,其细胞活性及细胞增殖指数等都明显优于hpcs及cs海绵。因此,对壳聚糖拓扑结构的这种设计不仅弥补了常规冻干支架的缺陷,提高了细胞相容性,还将表面图案化改性应用延伸到了三维尺度。
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