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OALib Journal期刊
ISSN: 2333-9721
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菌群失调小鼠腹泻造模及超微中药干预过程中肠道微生物的变化
DOI: 10.3724/SP.J.1145.2013.00449, PP. 449-453
Keywords: 超微中药,七味白术散,菌群失调,肠道微生物,中医药微生态
Abstract:
采用灌胃头孢拉定和硫酸庆大霉素混合抗生素进行小鼠菌群失调腹泻造模，灌胃给药1/2量超微七味白术散治疗，正常组和模型组灌胃等量的无菌水，在不同时间段取肠道内容物分析5类可培养微生物的数量，研究其动态变化.结果显示造模过程中，细菌总数、大肠杆菌数都是先急剧减少，后稍有恢复，但仍低于初始水平，乳酸菌数先急剧减少后又显著增加，高于正常组水平，酵母菌和霉菌数则呈现持续增加的趋势；经1/2量超微七味白术散治疗后，细菌总数持续增加，大肠杆菌数呈先增后减的趋势，乳酸菌和酵母菌数则先增加，治疗4d后趋于稳定，霉菌则持续减少.研究表明1/2量超微七味白术散对菌群失调小鼠肠道菌群具有明显的调整作用，有效缩短了肠道菌群由失调到平衡的时间.
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