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OALib Journal期刊
ISSN: 2333-9721
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两栖动物线粒体基因组trna基因重复、丢失及其影响
DOI: 10.3724/SP.J.1145.2010.00822, PP. 822-827
Keywords: 两栖类,线粒体基因组,密码子使用偏好,trna基因重复,trna基因丢失
Abstract:
在脊椎动物线粒体基因组中，偶有trna基因重复或丢失事件发生，这些事件因与相应氨基酸转运密切关联而凸显重要.两栖类中，这些重复或丢失相对多样，可为相关研究提供良好素材.为了解这些事件对氨基酸对应的密码子使用偏好是否产生影响，本文引入统计方法，检测10种两栖类mtdna蛋白编码基因相对的同义密码子使用度（rscu）,并特别设计将发生trna基因重复或丢失物种与其近缘群进行对比分析.结果显示，trna基因的重复对密码子使用偏好没有显著的影响，推测可能与突变积累的时限和mtdna紧凑性有关.另外，trna基因丢失也未使相应氨基酸密码子使用偏好产生明显的改变.推测在两栖类中，“trna转入”和“trna反密码子摆动位点的超级摆动”可能是trna基因丢失的补偿方式.表3参31
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