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OALib Journal期刊
ISSN: 2333-9721
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茄科雷尔氏菌蛋白质相互作用网络预测及分析
DOI: 10.3724/SP.J.1145.2012.00139, PP. 139-146
Keywords: 茄科雷尔氏菌,蛋白质相互作用,蛋白质功能,蛋白质组学,青枯病,朴素贝叶斯模型
Abstract:
细菌性青枯病是由茄科雷尔氏菌（ralstoniasolanacearum）引起的一种世界范围的细菌性土传病害.该细菌基因组序列的完全测序，使得从蛋白质组角度来分析其蛋白质相互作用网络成为可能.本文通过朴素贝叶斯模型整合系统发生谱法、基因邻近法、基因融合法、操纵子法、同源映射法、微阵列法、域相互作用法等7种方法，并根据约？指数确定的阙值，预测了可信的茄科雷尔氏菌的蛋白质相互作用网络.对网络中的分泌子网络和信号转导进行了分析，提出可能的药物作用靶点（cyab、pild、fli、rsp1526、vsra、vsrb、pilh）.对于未注释的蛋白依据蛋白相互作用推测了部分蛋白质的功能.本文也提供了完全免费的在线数据库支持，提供了方便的茄科雷尔氏菌的蛋白相互作用的查询及相互作用数据和推测的蛋白质功能数据的查询和下载（http://www.scbmp.org.cn/rsoppi.php）.图8表1参25
| [1] | 12yuh,luscombenm,luhx,zhux,xiay,hanjd,bertinn,chungs,vidalm,gersteinm.annotationtransferetweengenomes:protein�proteininterologsandprotein-dnaregulogs.genomeres,2004,14(6):1107~1118
|
| [2] | 14domingosp,pazzanim.ontheoptimalityofthesimplebayesianclassifierunderzero-oneloss.machinelearning,1997,29:103~130
|
| [3] | 15fathmj,kolterr.abctransporters:bacterialexporters.microbiolrev,1993,57(4):995~1017
|
| [4] | 18vangijsegemf,genins,boucherc.conservationofsecretionpathwaysforpathogenicitydeterminantsofplantandanimalbacteria.trendsmicrobiol,1993,1:175~1801
|
| [5] | 19winanssc,burnsdl,christiepj.adaptationofaconjugaltransfersystemfortheexportofpathogenicmacromolecules.trendsmicrobiol,1996,4(2):64~68
|
| [6] | 20vassej,genins,freyp,boucherc,britob.thehrpbandhrpgregulatorygenesofralstoniasolanacearumarerequiredfordifferentstagesofthetomatorootinfectionprocess.molplantmicrobeinteract,2000,13(3):259~267
|
| [7] | 21gentschevi,dietrichg,goebelw.thee.colialpha�hemolysinsecretionsystemanditsuseinvaccinedevelopment.trendsmicrobiol,2002,10(1):39~45
|
| [8] | 22rossiero,starkenburgsr,cianciottonp.legionellapneumophilatypeiiproteinsecretionpromotesvirulenceinthea/jmousemodeloflegionnaires’diseasepneumonia.infectimmun,2004,72(1):310~321
|
| [9] | 23schellma.controlofvirulenceandpathogenicitygenesofralstoniasolanacearumbyanelaboratesensorynetwork.annurevphytopathol,2000,38:263~292
|
| [10] | 24alfanojr,collmera.typeⅲsecretionsystemeffectorprotein:doubleagentsinbacterialdiseaseandplantdefense.annurevphytopathol,2004,42:385~414
|
| [11] | 25yipck,kimbroughtg,felisehb,vuckovicm,thomasna,pfuetznerra,finlaybb,millersi,strynadkanc.structuralcharacterizationofthemolecularplatformfortypeiiisecretionsystemassembly.nature,2005,435(7042):702~707
|
| [12] | 1pellegrinim,marcotteem,thompsonmj,eisenbergd,yeatesd.assigningproteinfunctionsbycomparativegenomeanalysis:proteinphylogeneticprofiles.procnatlacadsciusa,1999,96:4285~4288
|
| [13] | 2overbeekr,fonsteinm,d’souzam,puschgd,maltsevn.theuseofgeneclusterstoinferfunctionalcoupling.procnatlacadsci,1999,96:2896~2901
|
| [14] | 3strongm,mallickp,pellegrinim,thompsonmj,eisenbergd.inferenceofproteinfunctionandproteinlinkagesinmycobacteriumtuberculosisbasedonprokaryoticgenomeorganization:acombinedcomputationalapproach.genomebiol,2003,4:r59
|
| [15] | 4marcotteem,pellegrinim,nghl,ricedw,yeatesto,eisenbergd.detectingproteinfunctionandprotein-proteininteractionsfromgenomesequences.science,1999,285:751~753
|
| [16] | 5marcottecjv,marcotteem.predictingfunctionallinkagesfromgenefusionswithconfidence.applbioinformatics,2002,1(2):93~100
|
| [17] | 6matthewslr,vagliop,reboulj,geh,davisbp,garrelsj,vincents,vidalm.identificationofpotentialinteractionnetworksusingsequence-basedsearchesforconservedprotein�proteininteractionsor“interologs”.genomeres,2001,11(12):2120~2126
|
| [18] | 7ngsk,zhangz,tansh,link.interdom:adatabaseofputativeinteractingproteindomainsforvalidatingpredictedproteininteractionsandcomplexes.nucleicacidsres,2003,31(1):251~254
|
| [19] | 8geh,liuz,churchgm.correlationbetweentranscriptomeandinteractomemappingdatafromsaccharomycescerevisiae.natgenet,2001,29(4):482~486
|
| [20] | 9sunjc,xujl,liuz,liuq,zhaoa,shitl,liyx.refinedphylogeneticprofilesmethodforpredictingprotein-proteininteractions.bioinformatics,2005,21(16):3409~3415
|
| [21] | 10datesv,marcotteem.discoveryofuncharacterizedcellularsystemsbygenome-wideanalysisoffunctionallinkages.natbiotechnol,2003,21(9):1055~1062
|
| [22] | 11dandekart,snelb,huynenm,borkp.conservationofgeneorder:afingerprintofproteinsthatphysicallyinteract.trendsbiochemsci,1998,23(9):324~328
|
| [23] | 13handdj,yuk.idiot’sbayes-notsostupidafterall?internstatrev,2001,69(3):385~398
|
| [24] | 16finlaybb,falkows.commonthemesinmicrobialpathogenicityrevisited.microbiolmolbiolrev,1997,61(2):136~169
|
| [25] | 17salmondgp,reevespj.membranetrafficwardensandproteinsecretioningram-negativebacteria.trendsbiochemsci,1993,18(1):7~12
|
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