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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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毛兰素诱导结肠癌sw480细胞凋亡的分子机制
DOI: 10.3724/SP.J.1145.2011.00512, PP. 512-516
Keywords: 毛兰素,人结肠癌细胞sw480,细胞增殖,细胞凋亡,细胞周期,石斛,中药
Abstract:
毛兰素是名贵中药材石斛的活性化合物之一，研究了其对人结肠癌sw480细胞的增殖抑制作用及其诱导的细胞凋亡分子机制.实验表明，毛兰素能显著抑制结肠癌sw480细胞的增殖，且随着药物浓度与时间增加，抑制率呈明显的剂量时间效应，48h半数抑制浓度ic50为24.5nmol/l；毛兰素能显著诱导结肠癌sw480细胞凋亡，并诱导细胞周期阻滞于g2-m期；分子机制研究显示，毛兰素通过下调xiap、bcl-xl蛋白表达以及激活caspase-9、caspase-7、caspase-3和parp活性从而诱导sw480细胞凋亡.结果表明毛兰素可能对结肠癌的防治具有潜在药用价值.图6参17
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