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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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热休克、polyi:c上调草鱼grp78基因表达
DOI: 10.3724/SP.J.1145.2009.00814, PP. 814-818
Keywords: 热休克,polyi:c,表达,grp78,草鱼,胁迫
Abstract:
葡萄糖调节蛋白78（grp78）是细胞内一种应急蛋白，它通过对细胞内、外胁迫因子产生强烈的应答而调节内质网稳态.草鱼（ctenopharyngodonidellus）grp78克隆于草鱼肝肾cdna文库，全长2490bp.其中，5’非编码区为155bp，含有7个热休克元件，3’非编码区为373bp，最大开放阅读框为1962bp，编码653个氨基酸.序列分析表明，草鱼grp78的n端包含3个hsp70家族的签名序列，c末端为内质网蛋白滞留信号kdel，草鱼grp78与人及其它动物的同源性很高.适应性进化分析也显示grp78非常保守，受到强烈的功能约束，说明该蛋白质在进化中非常重要.rt-pcr分析表明，相对于本底水平，34℃热激和polyi:c诱导后，草鱼grp78在肝、肾等组织中的表达明显上调.图4表1参16
| [1] | 3zhangy(张莹),shunlg(孙黎光).grp78的研究进展.formedscisectpathophysiol&clinmed(国际病理科学与临床杂志),2005,25(3):251~253
|
| [2] | 4liuf,inagedak,nishitaig,matsuokam.cadmiuminducestheexpressionofgrp78,anendoplasmicreticulummolecularchaperone,inllc-pk1renalepithelialcells.environhealthperspect,2006,114(6):859~864
|
| [3] | 5qianyc,zhengy,ramosks,tiffany-castiglionie.grp78compartmentalizedredistributioninpb-treatedglia:roleofgrp78inlead-inducedoxidativestress.neurotoxicology,2005,26(2):267~275
|
| [4] | 7misrauk,mariogg,gawdig,wangf,pizzosv.anovelreceptorfunctionfortheheatshockproteingrp78:silencingofgrp78geneexpressionattenuatesα2m-inducedsignaling.cellsignaling,2004,16(8):929~938
|
| [5] | 10haasig.bip(grp78),anessentialhsp70residentproteinintheendoplasmicreticulum.cell&mollifesci,1994,50(11-12):1012~1020
|
| [6] | 11shaosh(邵淑红),panf(潘芳).葡萄糖调节蛋白的生物学特性及其在应激免疫应答中的作用.chinjbehavmedsci(中国行为医学科学),2004,13(6):711~712
|
| [7] | 12motepl,tillmanjb,spindlersr.glucoseregulationofgrp78geneexpression.mechageingdev,1998,104(2):149~158
|
| [8] | 13kaufmanrj,scheunerd,schröderm,shenx,leek,liucy,arnoldsm.theunfoldedproteinresponseinnutrientsensinganddifferentiation.natrevmolcellbiol,2002,3(6):411~421
|
| [9] | 1iwamagk,thomaspt,forsythrb,vijayanmm.heatshockproteinexpressioninfish.revfishbiol&fisheries,1998,8(1):35~56
|
| [10] | 2kiangjg,tsokosgc.heatshockprotein70kda:molecularbiology,biochemistry,andphysiology.pharmacolther,1998,80(2):183~201
|
| [11] | 6melnickj,duljl,argony.sequentialinteractionofthechaperonesbipandgrp94withimmunoglobulinchainsintheendoplasmicreticulum.nature,1994,370:373~375
|
| [12] | 8ojiman,yamashitam,watabes.quantitativemrnaexpressionprofilingofheat-shockproteinfamiliesinrainbowtroutcells.biochembiophysrescommun,2005,329(1):51~57
|
| [13] | 9nicholsonrc,williamsdb,moranla.anessentialmemberofthehsp70genefamilyofsaccharomycescerevisiaeishomologoustoimmunoglobulinheavychainbindingprotein.procnatlacadsciusa,1990,87(3):1159~1163
|
| [14] | 14sunsw,chungmc,linty.thestructureandexpressionofanhsc70genefromlycopersiconesculentum.gene,1996,170(2):237~241
|
| [15] | 15luanw,lifh,zhangjq,wangb,xiangj.cloningandexpressionofglucoseregulatedprotein78(grp78)infenneropenaeuschinensis.molbiolrep,2009,36(2):289~298
|
| [16] | 16leeas.theerchaperoneandsignalingregulatorgrp78/bipasamonitorofendoplasmicreticulumstress.methods,2005,35(4):373~381
|
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