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OALib Journal期刊
ISSN: 2333-9721
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慢性吸入二氧化氮诱发大鼠dna-蛋白质交联和微核效应
DOI: 10.3724/SP.J.1145.2013.00941, PP. 941-944
Keywords: no2,大鼠,dna-蛋白质交联,微核
Abstract:
为了探讨二氧化氮（no2）慢性、低浓度暴露对机体的遗传损伤作用，通过建立整体动物动式染毒模型，以不同浓度no2（0.25、5mgm-3）对大鼠进行慢性熏气染毒处理，考察了大鼠不同脏器（脑、肺、肝、肾、脾、心）dna-蛋白质交联系数及骨髓微核发生率的变化.结果表明，no2慢性暴露可导致大鼠不同脏器dna-蛋白质交联度升高，诱导骨髓微核发生率增加，存在明显的浓度-效应关系，高浓度时表现更为明显，与对照组比较具有统计学差异（p＜0.05），这可能是其慢性、低浓度暴露引发健康危害的一个重要原因.
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