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OALib Journal期刊
ISSN: 2333-9721
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基于主客体识别的温度及氧化还原双重响应型磁性聚合物胶束
DOI: 10.3724/SP.J.1145.2015.01024, PP. 596-601
Keywords: 主客体识别,磁性纳米粒子,双重响应性,胶束,药物载体
Abstract:
制备磁性纳米粒子和聚合物的复合材料是研究热点，而如何简单高效地构建磁性纳米粒子和聚合物的复合体系是目前研究的难点.基于此，本研究首先分别制备主体分子cd-mnps和客体分子mpeg-fc及pnipam-fc，利用β-cd和二茂铁基团之间的主客体识别作用，在磁性纳米粒子表面构筑两种亲疏水性不同的聚合物链，通过控制温度的变化，使其在水中发生组装，同时通过氧化还原电位的变化，实现组装体系形成和瓦解的可逆变化.并对得到的胶束进行了载药性能的表征.tem和dls的结果显示得到了粒径大概为250nm的磁性聚合物胶束，并可以通过温度和氧化还原的变化实现胶束的形成和瓦解，而且这种胶束可以作为药物载体，其对抗癌药物阿霉素（dox）的包封率高达73%.综上，本研究得到了一种兼具温度和氧化还原敏感的磁性聚合物胶束，这种新型的胶束在药物释放和磁共振成像方面具有潜在的应用前景.
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