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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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从原料到产品：生物基丁二酸研究进展
DOI: 10.3724/SP.J.1145.2014.07024, PP. 10-21
Keywords: 丁二酸,代谢工程,artp,基因组重排技术,原位分离法
Abstract:
丁二酸作为一种重要的有机化工原料及中间体，广泛用于生物高分子、食品与医药等行业，市场潜在需求量巨大；同时作为一种优秀的c4平台化合物，被认为是未来12种最具发展前景的生物炼制产品之一.近年来随着石化资源的日益枯竭及环境污染问题的日益严峻，以生物质为原料生产丁二酸等生物基产品的研究备受国内外研究者的关注.本文从产丁二酸菌种的种类及常见菌株产丁二酸的代谢途径、产丁二酸工程菌的改造、丁二酸发酵过程控制与优化、丁二酸的分离提取工艺等4个方面综述近年来国内外生物基丁二酸研究进展，其中以产丁二酸工程菌的改造为重点展开详细阐述.为提高菌株产丁二酸的能力，研究者们常采用代谢工程技术改造菌株，皆取得显著效果.近来也出现了利用artp法和基因组重排技术选育高产丁二酸的菌株.此外，高效的丁二酸发酵与其发酵原料，发酵过程中相关控制因素如ph、co2和h2浓度以及发酵方式密切相关；相比其他的丁二酸分离法，原位分离法回收丁二酸具备优势.最后对产丁二酸菌种的改造进行展望，认为利用适应性进化和最小基因组等技术筛选优良丁二酸生产菌是未来的趋势.
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