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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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卡瓦胡椒素b对人非小细胞肺癌a549细胞的抑制作用
DOI: 10.3724/SP.J.1145.2012.00740, PP. 740-744
Keywords: 卡瓦胡椒素b,肺癌细胞a549,细胞增殖,细胞凋亡,survivin,jnk
Abstract:
卡瓦胡椒素b是药用植物卡瓦胡椒根中的一种天然查耳酮类化合物，研究了其对人非小细胞肺癌a549细胞的增殖抑制作用及其诱导细胞凋亡的分子机制.实验结果显示，卡瓦胡椒素b能显著抑制非小细胞肺癌a549细胞的增殖，且随着药物浓度的增加、处理时间的延长其抑制作用呈明显的剂量时间效应；同时，卡瓦胡椒素b能显著诱导a549细胞凋亡、细胞周期阻滞于g2-m期；分子机制研究表明，卡瓦胡椒素b能通过活化jnk激酶活性、下调凋亡抑制蛋白survivin的表达以及激活parp活性从而导致其对a549细胞的增殖抑制作用.结果表明卡瓦胡椒素b对人非小细胞肺癌的预防与治疗可能具有潜在价值.图5参16
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