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OALib Journal期刊
ISSN: 2333-9721
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人血清白蛋白功能化的磁性纳米粒子对掌叶大黄的配体垂钓
DOI: 10.3724/SP.J.1145.2013.00164, PP. 164-167
Keywords: 配体垂钓,磁性纳米粒子,人血清白蛋白,掌叶大黄,活性小分子
Abstract:
掌叶大黄是中国传统的药用植物，其主要活性成分为蒽醌类化合物.利用人血清白蛋白（humanserumalbumin，hsa）功能化的磁性纳米粒子（magneticnanoparticles，mnps）为固相萃取材料，对掌叶大黄的水提取液进行配体垂钓研究，从中捕获到两个hsa的配体；结合质谱鉴定其结构分别为大黄素和大黄酚.基于磁性纳米粒子的配体垂钓技术可为从传统药用植物中寻找hsa的小分子配体提供一个简便有效的方法.
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