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OALib Journal期刊
ISSN: 2333-9721
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氧化微杆菌c3催化3,5-双三氟甲基苯乙酮的不对称反-prelog还原[英文]
DOI: 10.3724/SP.J.1145.2013.00037, PP. 37-42
Keywords: 生物还原,氧化微杆菌c3,阿瑞匹坦,(r)-3,5-双三氟甲基-1-苯乙醇
Abstract:
(r)-3,5-双三氟甲基-1-苯乙醇是合成神经激肽1受体拮抗剂阿瑞匹坦的关键手性醇中间体.通过筛选得到一株氧化微杆菌c3（microbacteriumoxydansc3），其能不对称还原底物3,5-双三氟甲基苯乙酮为(r)-3,5-双三氟甲基-1-苯乙醇.在底物浓度为5g/l时，生物转化反应40h，能达到>99%的ee值和95%的底物转化率.底物浓度提高到50g/l时，生物转化的ee值依然保持99%，并能达到56%的底物转化率.利用该氧化微杆菌c3对其他含氟苯乙酮衍生物进行生物转化反应，同样得到了较高的立体选择性和底物转化率.
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