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OALib Journal期刊
ISSN: 2333-9721
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一种新的加权功能相似性算法在蛋白质相互作用研究中的应用
DOI: 10.3724/SP.J.1145.2010.00420, PP. 420-423
Keywords: 语义相似性,功能相似性,蛋白质相互作用,go术语,wfcsim方法
Abstract:
基于go术语衡量基因产物之间的相似性主要是通过语义相似性进行，此类方法主要是先计算go术语之间的相似性，然后再通过与go术语相关的基因产物的相似性两步来实现的.第一步go术语之间的相似性已经有了大量的研究，但是关于第二步的功能相似性研究却很少，针对平均化计算功能相似性的一些缺陷，提出了一种新的加权的功能相似性计算方法――wfcsim方法.应用dip数据库中人类和线虫的蛋白质相互作用数据，通过roc曲线对基于平均化、基于最大化、wang和wfcsim等4种功能相似性研究方法进行了评估，结果表明，与前人通常使用的基于平均的方法相比，wfcsim方法在功能相似性分析方面具有较高的优越性.图3参15
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