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OALib Journal期刊
ISSN: 2333-9721
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毛兰素对人肝癌huh7细胞的抑制作用
DOI: 10.3724/SP.J.1145.2011.00662, PP. 662-665
Keywords: 毛兰素,人肝癌细胞huh7,细胞增殖,细胞凋亡,细胞周期
Abstract:
研究了从鼓槌石斛中分离得到的低分子量天然化合物毛兰素在体外对人肝癌huh7细胞的增殖抑制作用，并探讨其诱导细胞凋亡的分子机制.实验结果显示：毛兰素能显著抑制肝癌huh7细胞的增殖，且随着药物浓度与时间增加其抑制率呈明显的剂量时间效应，其48h半数抑制浓度ic50为37.4nmol/l；毛兰素能诱导人肝癌huh7细胞凋亡并使其细胞周期阻滞于g2-m期；分子机制研究显示毛兰素可抑制akt激酶活性、下调mcl-1蛋白表达以及激活parp活性从而导致其对huh7癌细胞的增殖抑制作用.以上结果初步表明毛兰素对肝癌防治具有潜在药用价值.图5参17
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