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OALib Journal期刊
ISSN: 2333-9721
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聚类go术语在基因表达差异研究中的应用
DOI: 10.3724/SP.J.1145.2011.00422, PP. 422-426
Keywords: 基因本体,层次聚类,基因差异表达,语义相似性
Abstract:
针对基因功能分类体系基因本体（geneontology，go）特殊的有向无环图特点，改进传统的用单个go术语检测基因差异表达信号的缺陷，设计出“聚类go术语提升差异表达检测（scago）”算法.通过简单的输入对照和实验组表达谱上的全部基因表达信号，来研究一些比较新的差异表达功能组，有助于进一步解释基因差异表达的生物学意义，如疾病发病机制、药物作用机理等.将scago和基于单go术语差异分析法应用到急性淋巴细胞性白血病数据集和酵母rap1dna绑定突变体差异表达数据集上，结果显示，scago能比基于单go术语差异分析法发现一些新的与差异表达相关联的功能类基因，对于指导实验具有积极意义.图1表3参21
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