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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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口腔癌及癌前病变中fhit与cyclind1/cdk4表达的相关性研究
, PP. 812-814
Keywords: fhit,cyclind1,cdk4,口腔癌,癌前病变
Abstract:
目的通过检测cyclind1/cdk4在口腔鳞癌(oscc)及癌前病变中的表达,并分析它们在口腔癌中的作用及相关关系。方法采用免疫组化sp法检测64例oscc、39例口腔癌前病变、12例正常口腔粘膜中cyclind1、cdk4蛋白表达的情况,并比较其相关性。结果cyclind1/cdk4在oscc组中的表达明显高于正常组和癌前病变组(p<0.01)。spearman等级相关分析表明fhit与cyclind1、cdk4之间相关性不明显,而cyclind1、cdk4之间有正相关关系。结论fhit、cyclind1、cdk4在oscc的发生和发展过程中起着一定的作用。fhit可能并不通过影响cyclind1/cdk4来发挥其功能。
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