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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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近50年宫颈癌的发病趋势和临床特点分析
, PP. 605-609
Keywords: 宫颈肿瘤,流行病学,组织病理学,新辅助化疗
Abstract:
目的分析近50年宫颈癌的发病趋势和临床特点,探讨合理的治疗方案。方法对1955年1月至2004年12月收治的1557例浸润性宫颈癌的临床和病理资料进行回顾性分析。结果近50年来宫颈癌的平均发病年龄逐渐降低,由1955~1964年的(56.27±8.45)岁降至1995~2004的(43.81±8.90)岁;年轻宫颈癌(≤35岁)的构成比由3.42%升至24.91%。同时,临床早期(ⅰ~ⅱ期)的比例和非鳞癌的比例则逐步升高,差异均有统计学意义(p<0.05)。不同年龄组病例的临床分期、病理类型及淋巴结转移率比较,差异均有统计学意义(p<0.05),尤其是年轻人宫颈癌与其他年龄组比较,具有非鳞癌比例高、淋巴结转移率高和临床晚期(ⅲ~ⅳ期)比例高等显著特点。针对宫颈癌发病的新趋势和临床特点,改变传统的治疗模式、探索相应的治疗新方法十分必要。结论近50年宫颈癌的发病具有明显年轻化、及临床早期比例和非鳞癌比例逐步升高的趋势。与其他年龄组比较,年轻人宫颈癌具有显著不同的临床和病理特点。对于生育年龄宫颈癌的治疗应充分考虑其生殖内分泌功能的保留问题。新辅助动脉化疗是现代宫颈癌治疗的有效手段之一。
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