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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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鸸鹋油对烫伤大鼠创面的抗炎及促愈合作用
, PP. 407-410
Keywords: 烧伤,鸸鹋油,炎症,创面,创面愈合
Abstract:
目的从炎症反应的角度探讨外用鸸鹋油对烫伤大鼠创面愈合的影响。方法建立10%体表面积浅ⅱ度烫伤大鼠模型,将144只雄性wistar大鼠随机分为a、b、c组,分别外用生理盐水、碘伏、鸸鹋油治疗,观察创面的大体变化及愈合情况,分别留取不同时相的创面和血液标本,进行组织病理学检查和含水量测定(干湿重法)、elisa法检测组织和血浆tnfα含量。结果外用鸸鹋油可使创面肿胀、渗出减轻,创面无感染迹象,未见任何副作用;病理形态学观察发现鸸鹋油可使局部组织炎症反应减轻,与a、b组相比较,以伤后1、3d差异最为明显;c组伤后3d组织含水量及tnf-α含量明显减少(p<0.01),两者之间存在正相关关系(p<0.001);可使创面愈合时间缩短(p<0.01),促进创面再上皮化和表皮各层的分化。结论在浅ⅱ度烫伤创面外用鸸鹋油具有抗炎作用,可能与局部组织中促炎细胞因子水平的降低有关;并能促进创面愈合,可能与其抑制局部组织的继发性炎症反应有关。
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