|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
非体外循环主动脉-冠状窦分流逆行灌注对急性缺血心肌的保护
, PP. 457-461
Keywords: 急性心肌缺血,经冠状窦逆行灌注,心肌保护,缺血再灌注损伤
Abstract:
目的探讨在非体外循环心脏不停跳经冠状窦持续灌注动脉血对急性心肌缺血的保护作用和安全性。方法实验猪通过套扎冠状动脉前降支120min复制急性心肌缺血模型,然后松解套扎线60min恢复灌注。随机分为3组:第1组为对照组,在第2、3组,缺血60min后接受主动脉-冠状静脉窦分流进行逆灌60min,冠状窦压分别控制在40~50mmhg(低压组)和70~80mmhg(高压组)。术中测定各时点血流动力学和冠状窦静脉血一氧化氮(no)和内皮素-1(et-1)变化,术毕测定左心室心肌梗塞范围。结果在缺血180min,第2、3组左室压上升或下降速率(±dp/dtmax)比对照组提高,no浓度较高而et-1较低,心梗面积分别比对照组减少45%和61%。结论非体外循环下经冠状窦逆行灌注可以减少急性缺血/再灌注后左室收缩和舒张功能不全和内皮细胞损伤,高压逆灌可以抢救更多的濒危心肌。
| [1] | ruengsakulrachp,buxtonbf.anatomicandhemodynamicconsiderationsinfluencingtheefficacyofretrogradecardioplegia[j].annthoracsurg,2001,71:1389-95.
|
| [2] | gundrysr,wangn,sciolarocm,etal.uniformityofperfusioninallregionsofthehumanheartbywarmcontinuousretrogradecardioplegia[j].annthoracsurg,1996,61(1):33-5.
|
| [3] | tiang,shenj,sunjk,etal.doessimultaneousantegrade/retrogradecardioplegiaimprovemyocardialperfusionintheareasatrisk?amagneticresonanceperfusionimagingstudyinisolatedpighearts[j].jcardiovascsurg,1998,115:913-24.
|
| [4] | güdenm,akpinarb,bayindiro,etal.earlymyocardialresuscitationviacoronarysinusperfusion[j].asiancardiovascthoracann,2000,8:330-2.
|
| [5] | al-ruzzehs,nakamurak,athanasiout,etal.doesoff-pumpcoronaryarterybypass(opcab)surgeryimprovetheoutcomeinhigh-riskpatients:acomparativestudyof1398high-riskpatients[j].eurjcardiothoracsurg,2003,23(1):50-5.
|
| [6] | martinjs,byrnejg,ghezoy,etal.lv-poweredcoronarysinusretroperfusionreducesinfarctsizeinacutelyischemicpigs[j].annthoracsurg,2000,69:84-9.
|
| [7] | wakiday,nordlanderr,kobayashis,etal.short-termsynchronizedretroperfusionbeforereperfusionreducesinfarctsizeafterprolongedischemiaindogs[j].circulation,1993,88(partⅰ):2370-80.
|
| [8] | aldeags,zhangx,riverss,etal.salvageofischemicmyocardiumwithsimplifiedandevendelayedcoronarysinusretroperfusion[j].annthoracsurg,1996,62:9-15.
|
| [9] | 吴永健,陈在嘉,徐义枢,等.猪心肌缺血再灌注时冠状静脉窦血中内皮素的变化和大剂量维生素c对其影响[j].中国循环杂志(chinjcirc),1995,10:611-3.
|
| [10] | gearygg,smithgt,suehirogt,etal.quantitativeassessmentofinfarctsizereductionbycoronaryvenousretroperfusioninbaboons[j].amcardiol,1982,50:1425-30.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
