|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
卡托普利和洛沙坦对大鼠肾脏水通道蛋白-2mrna和尿液水通道蛋白-2的影响
, PP. 391-394
Keywords: 水通道蛋白2,血管加压素2型受体,卡托普利,洛沙坦
Abstract:
目的探讨卡托普利和洛沙坦对正常大鼠肾脏水通道蛋白-2(aqp2)mrna表达的影响及尿液水通道蛋白-2浓度的改变。方法30只健康大鼠随机分成3组:正常对照组,卡托普利组,洛沙坦组。经用药后观察血na+、尿量以及尿渗量水平,用rt-pcr半定量检测肾内髓质aqp2及血管加压素2型(v2)受体mrna水平,用酶联免疫吸附测定法检测尿液aqp2浓度。结果卡托普利组与洛沙坦组大鼠尿量均较正常组显著增多,卡托普利组尿渗量低于洛沙坦组和正常组,但尿液中aqp2浓度却高于洛沙坦组和正常组。rt-pcr半定量显示卡托普利组aqp2mrna较正常组显著降低(p<0.05),v2受体mrna没有显著差别。结论卡托普利可以抑制正常大鼠肾内髓质aqp2mrna的表达,同时促进肾内aqp2经尿液排出。
| [1] | nielsens,agrep.theaquaporinfamilyofwaterchannelsinkidney[j].kidneyint,1995,48(4):1057-68.
|
| [2] | gallardop,cidlp,viocp,etal.aquaporin-2,aregulatedwaterchannel,isexpressedinapicalmembranesofratdistalcolonepithelium[j].amjphysiol,2001,281(3):g856-63.
|
| [3] | 许顶立,任昊.慢性心力衰竭水潴留机制的研究进展[j].第一军医大学学报(jfirstmilmeduniv/diyijunyidaxuexuebao),2001,21(1):65-7.
|
| [4] | staahltoftd,nielsens,janjuanr,etal.losartantreatmentnormalizesrenalsodiumandwaterhandlinginratswithmildcongestiveheartfailure[j].amjphysiolrenalphysiol,2002,282(2):f307-15.
|
| [5] | fukuok.enhancementofnobioavailabilitybyaceiandarb[j].nipponrinsho,2004,62(9):561-6.
|
| [6] | cadnapaphornchaima,rogachevb,summersn,etal.evidenceforbradykininasastimulatorofthirst[j].amjphysiolrenalphysiol,2004,286(5):f875-80.
|
| [7] | muraset,tiany,fangxy,etal.synergisticeffectsofnitricoxideandprostaglandinsonrenalescapefromvasopressin-inducedantidiuresis[j].amjphysiolregulintegrcompphysiol,2003,284(2):r354-62.
|
| [8] | buemim,dipasqualeg,ruelloa,etal.effectofaprostacyclinanalogue,iloprost,onurinaryaquaporin-2excretioninhumans[j].nephron,2002,91(2):197-202.
|
| [9] | 许顶立,任昊,martinpy,等.充血性心力衰竭大鼠肾脏aqua-porin2水通道蛋白基因的表达[j].中华医学杂志,1998,78(2):118-20xudl,renh,martinpy,etal.renalaquaporin-2waterchannelexpressionincongestiveheartfailurerat[j].natlmedjchin,1998,78(2):118-20.
|
| [10] | 卢武生,许顶立,殷晓燕,等.尿液水通道蛋白-2体夹心elisa测定法的建立[j].第一军医大学学报,2002,22(6):486-9luws,xudl,yinxy,etal.enzyme-linkedimmunosorbentassayforurinaryaquaporin-2waterchannelproteinmeasurement[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2002,22(6):486-9.
|
| [11] | laskime,pressleyta.aquaporinmediatedwaterfluxasatargetfordiureticdevelopment[j].seminnephrol,1999,19(6):533-50.
|
| [12] | hebertpr,foodyjm,hennekensch.therenin-angiotensinsystem:theroleofinhibitors,blockers,andgeneticpolymorphismsinthetreatmentandpreventionofheartfailure[j].currvascpharmacol,2003,1(1):33-9.
|
| [13] | yucm,winghonlaik,lips,etal.normalizationofrenalaquaporin-2waterchannelexpressionbyfosinopril,valsartan,andcombinationtherapyincongestiveheartfailure:anewmechanismofaction[j].jmolcellcardiol,2004,36(3):445-53.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
