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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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阿霉素碘油乳犬肝动脉栓塞后的靶向性及药代动力学特征
, PP. 1428-1430
Keywords: 阿霉素/药代动力学,阿霉素碘油乳,栓塞,治疗性,高效液相色谱法
Abstract:
目的研究阿霉素碘油乳(ad-e)经肝动脉栓塞后的靶向特征及体内药代动力学过程。方法经犬肝动脉注入ad-e,用高效液相色谱(hplc)荧光检测外周静脉血和肝栓塞部位组织中阿霉素药物浓度,并与阿霉素溶液给药组对照。结果ad-e组外周静脉阿霉素血药浓度显著低于阿霉素组,其t1/2β为阿霉素组的1.51倍。给药后10、24和48h,ad-e组肝组织中阿霉素浓度分别为阿霉素组的5.42、3.33、和2.38倍。结论ad-e肝动脉栓塞给药明显改变阿霉素犬体内的药代动力学过程及肝组织靶向定位特征。
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