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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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血管内皮生长因子与nm23-h1基因在青年女性乳腺癌组织中的表达及其与预后之间的关系
, PP. 1398-1401
Keywords: 乳腺肿瘤,血管内皮生长因子,nm23基因,预后
Abstract:
目的探讨血管内皮生长因子(vegf)及nm23-h1基因在青年女性乳腺癌组织中的表达及其与预后间的关系。方法应用免疫组化方法检测48例青年女性、30例绝经后乳腺癌组织及10例乳腺纤维腺瘤组织中vegf及nm23-h1基因的表达情况,分析他们之间及其与临床病理指标之间的关系,并随访患者5年生存率。结果青年组较绝经组患者淋巴转移率高(p<0.01);青年组与绝经组患者组织中,vegf及nm23-h1的表达差异皆有显著性意义(p<0.01);青年组、绝经组以及乳腺纤维腺瘤组,两者表达差异也有显著性意义(p<0.01,p<0.01);各组中腋窝淋巴结转移者和未转移者vegf及nm23-h1的表达差异均有显著性意义(p<0.01);各组中vegf及nm23-h1的表达与组织分化程度无关(p>0.05);青年乳腺癌组织中vegf与nm23-h1基因表达成负相关(p<0.01),随访发现:青年乳腺癌患者nm23-h1阳性者5年生存率显著高于p53阳性者生存率(p<0.05)。结论vegf及nm23-h1基因的表达状况标志着青年乳腺癌恶性侵袭程度,因而二者可作为青年乳腺癌患者极有价值的生物学预后指标。
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