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OALib Journal期刊
ISSN: 2333-9721
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三剂赛尼哌在肝移植中应用的临床研究
, PP. 729-732
Keywords: 肝移植,赛尼哌,同种移植物急性排斥
Abstract:
目的探讨三剂赛尼哌在预防同种异体原位肝移植术后早期急性排斥反应(ar)发生的作用,以及联合他克莫斯(fks06)、霉酚酸酯(mmf)、皮质类固醇的效果、安全性。方法原位肝移植患者13例,手术前后应用三剂赛尼哌并联合三联免疫治疗,观察术后30d内ar的发生次数及反应程度,移植肝功能的恢复时间,fk506用量及血药浓度变化,感染性疾病及不良反应。将上述结果与国内外同类研究结果相对照。结果本组病人共发生ar1例,发生时间分别为术后17d,应用甲基强地松龙(mp)冲击治疗好转;死亡3例,分别于术后14、19、23d死于肺部真菌感染、移植肝动脉狭窄所致肝衰竭、多器官衰竭;移植肝功能的恢复时间在16.56±10.40d;共10例病人发生各种类型的感染fk506谷值血药浓度维持在(10.25±1.99)×10-3mg/l(w/v)未发生ar,未发现过敏反应及明显的不良反应。结论三剂赛尼哌结合三联免疫抑制剂治疗或预防ar安全有效且无并发症。联合应用fk506时其谷值血药浓度维持在(10.25±1.99)×10-3mg/lg,用药量为5±2mg/d。
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