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OALib Journal期刊
ISSN: 2333-9721
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rhil-10对肿瘤坏死因子-α诱导的血管外膜成纤维细胞增殖的影响
, PP. 50-52
Keywords: 成纤维细胞/药物作用,白细胞介素-10,肿瘤坏死因子,细胞增殖
Abstract:
目的观察重组人白细胞介素-10(rhil-10)对肿瘤坏死因子-α(tnf-α)诱导的成纤维细胞增殖的影响。方法体外培养nih/3t3细胞,应用rhil-10与tnf-α共同作用并设立对照进行比较,采用mts/pes法确定nih/3t3细胞的增殖状态。应用流式细胞仪测定细胞周期。结果tnf-α对nih/3t3细胞增殖具有明显的刺激作用。rhil-10单独应用对nih/3t3细胞生长没有影响。在tnf-α刺激下,一定剂量的rhil-10可抑制nih/3t3细胞的增殖。rhil-10可使tnf-α作用下的nih/3t3细胞大部分处于g0/g1期。结论rhil-10能明显抑制由tnf-α刺激的成纤维细胞增殖。
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