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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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影响大鼠平滑肌细胞增殖的对比超声条件
, PP. 21-23
Keywords: 对比超声,声学造影剂,平滑肌细胞,大鼠,增殖
Abstract:
目的观察不同超声条件作用下声学造影剂对大鼠平滑肌增殖的影响。方法96孔板培养大鼠血管平滑肌细胞,加入微泡,不同超声条件作用后48h行锥虫蓝染色,采用mtt法确定血管平滑肌细胞的增殖状态。结果机械指数0.75以下,锥虫蓝染色未观察到细胞毒性作用;平滑肌细胞的增殖程度随超声机械指数升高而减低;照射时间60s、造影剂微泡浓度20%时,对平滑肌细胞的增殖程度达到最强。结论声学造影剂破坏对平滑肌增殖的抑制程度与超声机械指数、微泡浓度、超声照射时间有关。
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