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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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地塞米松磷酸钠脂质体经兔结肠粘膜的体外ussingchamber渗透研究
, PP. 11-14
Keywords: 地塞米松磷酸钠,脂质体,体外ussingchamber,结肠
Abstract:
目的观测并评价载药脂质体经结肠粘膜渗透的特点。方法制备地塞米松磷酸钠(dsp)脂质体,采用体外uss-ingchamber实验法,考察dsp经时经兔结肠粘膜的累积透过量及在粘膜内的分布量。结果和dsp溶液比较,dsp脂质体能延缓和减少dsp经结肠粘膜的透过量。dsp脂质体的表观渗透系数(×10-6,cm/s)为31.95±7.65,和dsp溶液(88.61±18.61)比较,具有显著差异。透过实验120min和300min时,dsp脂质体在结肠粘膜中的分布量均明显高于dsp溶液。结论和dsp溶液比较,dsp脂质体在治疗局部结肠炎时,可能具有更小的毒性,更高的疗效,值得进一步开发研究。
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