|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
st段抬高型急性心肌梗死溶栓治疗后不同抗凝治疗的临床观察
, PP. 81-84
Keywords: st段抬高型急性心肌梗死,溶栓治疗,肝素,新复先
Abstract:
目的观察比较st段抬高型急性心肌梗死溶栓治疗后普通肝素(ufh)和parnaparin(商品名新复先)两种不同抗凝辅助治疗方法的疗效和安全性。方法186名入院后接受溶栓治疗的st段抬高型急性心肌梗死患者随机分为2组,ufh组及parnaparin组。ufh组在溶栓治疗后12h给予肝素100u/kg？b.w.静脉推注,续1000u/h静脉滴注,维持活化的部分凝血活酶时间为正常对照的1.5~2.0倍,连续3d后改为皮下注射7500u每12h1次,连续注射4d。parna-parin组在溶栓治疗后12h给予parnaparin0.4ml皮下注射,每12h1次,连续注射7d。主要观察终点:治疗2、7、14、30d内发生心脏性或非心脏性死亡、再梗死、药物治疗疗效差而必须行急诊血运重建的三联终点事件(死亡、心肌再梗死、紧急血运重建术)。所有入选患者住院14d以上,随访至治疗后45d。结果随访45d内复合三联终点事件在par-naparin组明显下降(42.22%vs37.08%,p=0.03),出血事件(10.00%vs3.13%,p=0.06)及血小板减少(3.33%vs0,p=0.07)亦少于ufh组。结论做为st段抬高型急性心肌梗死溶栓治疗后的辅助抗凝治疗,parnaparin较ufh至少在45d内更能减少心脏事件的再发生,更少发生出血事件和血小板减少。
| [1] | 中华心血管病杂志编委会.急性心肌梗塞溶栓疗法参考方案[j].中华心血管杂志(chincardiovascj),1996,24(5):328-9.
|
| [2] | ryantj,antmanem,brooksnh,etal.update:acc/ahaguidelinesforthemanagementofpatientswithacutemyocardialinfarction.areportoftheamericancollegeofcardiology/americanheartassociationtaskforceonpracticeguidelines(committeeonmanagementofacutemyocardialinfarction)[j].jamcollcardiol,1999,34(3):890-911.
|
| [3] | fusterv,badimonl,badimonjj,etal.thepathogenesisofcoronaryarterydiseaseandtheacutecoronarysyndromes[j].nengljmed,1992,336(4):242-50.
|
| [4] | 刘东,唐斌,蒙善东,等.血液滤过在移植肾功能延迟恢复治疗中的应用[j].第一军医大学学报,2001,21(9):691-2.liud,tangb,mengsd,etal.clinicalstudyofhemofiltrationinthetreatmentofdelayedgraftfunction[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2001,21(9):691-2.
|
| [5] | 刘志强,王力,刘俊.国产与进口低分子肝素在血液透析中抗凝作用的比较[j].第一军医大学学报,2002,22(10):942-3.liuzq,wangl,liuj.comparisonofanticoagulationefficacyandclinicalsafetybetweenimportedanddomesticallymanufaciuredlow-molecular-weightheparinduringhemodialysis[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2002,22(10):942-3.
|
| [6] | 邵燕,章成国,孙炽津,等.颅内静脉系统血栓形成的早期诊断及治疗[j].第一军医大学学报,2003,23(2):184-6.shaoy,zhangcg,sunzj,etal.earlydiagnosisandtreatmentofintracranialvenousthrombosis[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2003,23(2):184-6.
|
| [7] | 高玉琪,李志�,丁明学.等.急性前壁心肌梗死急性期st段抬高形态与近期预后的关系[j].第一军医大学学报,2002,22(2):156-8.gaoyq,lizl,dingmx,etal.relationofthest-segmentelevationpatterninacutephaseofanteriorwallacutemyocardialinfarctiontoshort-termproguosis[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2002.22(2):156-8.
|
| [8] | 迟东升,刘伊丽,王鹏,等.超声心动图观察左室肥厚对评价高血压心肌微血管病变的价值[j].第一军医大学学报,2003,23(7):702-5.chids,liuyl,wangp,etal.valueofechocardiographyforobservingleftventricularhypertrophyinthediagnosisofmyocardialmicrovasculardamageinhypertensives[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2003,23(7):702-5.
|
| [9] | hirshj,levinemn.lowmolecularweightheparin[j].blood,1992,79(1):1-17.
|
| [10] | fareedj,hoppeusteadtda.pharmacologyoflowmolecularweightheparins[j].seminthrombhemost,1996,22(suppl2):13-8.
|
| [11] | weitzji.low-molecular-heparins[j].nengljmed,1997:337(10):688-98.
|
| [12] | jamesjj.lowmolecularheparinsandglycoproteinⅱb/ⅲaantagonists[j].jintervencardiol,2002,15(2):147-54.
|
| [13] | cohenm,antmanem,gurfmkele,etal.impactofenoxaparinlowmolecularweightheparininpatientswithq-wavemyocardialinfarction[j].amjcardiol,2000,86(5):553-6.
|
| [14] | bairdsh,menownba,mcbridesj,etal.randomizedcomparisonofenoxaparinwithunfracfionatedheparinfollowingfibrinolytictherapyforacutemyocardialinfarction[j].eurheartj,2002,23(8):627-32.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
