|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
人脑胶质瘤与人脑转移瘤中nf-κbp65的表达及意义
, PP. 75-78
Keywords: 胶质瘤,人脑,转移瘤,肿瘤浸润,核转录因子κbp65
Abstract:
目的研究人脑胶质瘤(hbg)与人脑转移瘤(hbmc)中核转录因子κbp65(nf-κbp65)的表达及其在肿瘤生物学行为中的作用。方法应用sabc方法进行免疫组织化学染色,观察6例正常人脑组织、18例hbg组织与12例hbmc组织中nf-κbp65的表达及与肿瘤生物学行为之间的关系。结果正常脑细胞中nf-κbp65仅微量表达,在hbg细胞与hbmc细胞中呈不同程度的表达;在高级别hbg、hbmc和复发型hbg中,表达水平较低级别hbg细胞的高(p<0.01)。结论nf-κbp65表达的增强与hbg和hbmc恶性程度的增高、肿瘤浸润关系密切,并在hbg的复发中起重要作用。
| [1] | vermaim,stevensonjk,schwarze,etal.rel/nf-kappab/ikappabfamily:intimatetalesofassociationanddissociation[j].genesdev,1995,9(22):2723-35.
|
| [2] | deshpander,khalilih,pergolizzi,etal.estrodioldownregulateslps-inducedcytokineproductionandnf-κbactivationinmurinemacrophage[j].amjreprodimmunol,1997,38(1):46-9.
|
| [3] | 张桂林,刘尚喜,邓燕,等.免疫化学染色图像分析法检测细胞核因子кb[j].第一军医大学学报,2003,23(5):498-51.zhanggl,liusx,dengy,etal.detectionofnuclearfactorkappabbyimmunochemicalstainingandimageanalysis[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2003,23(5):498-51.
|
| [4] | nagais,washiyamak,kurimotom,etal.aberrantnuclearfactor-kappabactivityanditsparticipationinthegrowthofhumanmalignantastrocytoma[j].jneurosurg,2002,96(5):909-17.
|
| [5] | 郭亚兵,戴琳,冯筱榕,等.杆状病毒载体介导的氯霉素乙酰转移酶基因在hepg2中的表达[j].第一军医大学学报,2001,21(9):648-51.guoyb,dail,fengxr,etal.baculovirus-mediatedgenetransferanditsexpressioninhepg2cells[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2001,21(9):648-51.
|
| [6] | 王群英,陈村龙,王继德,等.溃疡性结肠炎小鼠模型中细胞因子的表达和核转录因子кb的激活[j].第一军医大学学报,2003,23(11):1202-5.wangqy,chencl,wangjd,etal.expressionofpro-inflammationcytokinesandactivationofnuclearfactorκbintheintestinalmucosaofmicewithulcerativecolitis[j].jfirstmilmeduniv/diyijunyidaxuexuebao,2003,23(11):1202-5.
|
| [7] | natolig,costanzoa,morettip,etal.nuclearfactor-κb-independentcytoprotectivepathwaysoriginatingattumornecrosisfactorreceptor-associatedfactor2[j].jbiolchem,1998,273(47):312-62.
|
| [8] | nomuray,ueharat,nishiyat.theintracellularmechanismofnf-kappabactivationinvolvedininosandchemokineinductioninc6gliomacells[j].nipponyakurigakuzasshi,1999,114(suppl):92p-sp.
|
| [9] | feinsteindl,galeae,reisdj.suppressionofglialnitricoxidesynthesesinductionbyheatshock:effectsonproteolysisdegradationofikappab-alpha[j].nitricoxide,1997,1(2):167-76.
|
| [10] | hideshimat,chauhand,richardsonp,etal.nf-κbasatherapeutictargetinmultiplemyetoma[j].jbiochem,2002,277(19):16639-47.
|
| [11] | neildp,rolandms,colinsd,etal.distinctcombinationsofnfкbsubunitsdeterminethespecificityoftranscriptionalactivation[j].procnotlacadsciusa,1992,89(43):1529-34.
|
| [12] | delvallel,azizisa,krynskab,etal.reactivationofhumanneurotropicjcvirusexpressingoncogenicproteininarecurrentglioblastomamultiforme[j].annneurol,2000,48(6):932-6.
|
| [13] | 陈荛,刘执玉,李瑞相,等.人直肠腺癌淋巴管内皮细胞icam-1的转录调节[j].华西医科大学学报,2000,31(3):315-8.chenr,liuzy,lirx,etal.transcriptionregulationofintercellularadhesionmolecule((icam-1)onlymphafticendothelialcellsofrectumadenocarcinomaofhuman[j].jwestchinunimedsci,2000,31(3):315-8.
|
| [14] | nomuray.nf-kappabactivationandikappabalphadynamisminvolvedininosandchemokineinductioninastmgiialcells[j].lifesci,2001,68(15):1695-701.
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
