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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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吲哚美辛抑制结肠癌移植瘤生长和微血管形成的实验研究
, PP. 184-187
Keywords: 吲哚美辛,结肠肿瘤,血管生成,微血管密度,血管内皮生长因子
Abstract:
目的研究非甾体抗炎药吲哚美辛对人结肠癌hct116移植瘤生长和微血管形成的影响。方法建立人结肠癌裸鼠皮下移植瘤模型。随机分组:治疗组喂服吲哚美辛(3mg？kg-1？d-1),对照组给予相应体积溶剂(0.2%二甲亚砜-生理盐水溶液)。4周后处死动物,采用免疫组化法检测肿瘤微血管密度(mvd)及肿瘤组织中血管内皮生长因子(vegf)的表达,鼠抗人cd34标记微血管。结果治疗组与对照组皮下移植瘤体积分别为(458.89±32.07)mm3和(828.21±31.59)mm3(p<0.05),治疗组肿瘤生长受到明显抑制;瘤组织中mvd分别为19.50±5.32和37.40±4.93(p<0.001),vegf的表达强度分别为1.19±0.17和1.90±0.48(p<0.01),mvd与vegf变化呈正相关(rs=0.714,p<0.05)。实验结束时未见明显毒性反应。结论吲哚美辛能通过抑制肿瘤微血管形成发挥抗瘤作用,其机制可能与抑制vegf的表达有关。
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