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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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影响致敏患者移植肾存活的危险因素分析
Keywords: 肾移植,存活率,群体反应性抗体,危险因素
Abstract:
目的探讨影响致敏患者移植肾存活的危险因素,识别引起移植物失功的高危患者,以提高致敏患者移植肾长期存活率。方法选择102例行肾移植术的致敏患者进行回顾性研究,用kaplan-meier计算1、3、5年移植肾存活率,用log-rank进行单因素分析和cox模型多因素回归分析,计算相对危险度。结果102例致敏患者随访期间移植肾失功16例,其中死亡7例,术后1年内死亡5例,术后2及3年带肾死亡各1例。死亡原因肺部感染5例、心血管疾病2例,失访3例。1、3、5年人存活率为95%、93%和93%,1、3、5年肾存活率为90%、85%和75%,移植肾半生存期为8.9年。单因素及多因素分析表明受者年龄、移植次数、pra水平、术后pra水平升高、hla相配程度、移植肾功能恢复正常时间、移植肾功能延迟恢复、急性排斥反应、血肌酐水平、感染等10个因素对移植肾的存活产生重要或非常重要影响。结论通过控制影响移植肾存活的危险因素,致敏患者移植肾存活同样能取得满意效果。
| [1] | hariharans,johnsoncp,bresnahanba,etal.improvedgraftsurvivalafterrenaltransplantationintheunitestates.1988to1996[j].nengljmed,2000,342(9):605-12.
|
| [2] | 肖序仁,敖建华,李炎唐,等.肾移植1180例次生存分析[j].中华外科杂志,2000,38(8):578-81.xiaoxr,aojh,liyt,etal.survivalanalysisafterkidneytransplantationin1180cadavericgrafting[j].chinjsurg,2000,38(8):578-81.
|
| [3] | halloranpf,schlautj,solezk,etal.thesignificanceofanti-classⅰantibodyresponseⅱ.clinicalandpathologicfeaturesofrenaltransplantswithanti-classi-likeantibody[j].transplantation,1992,53(2):550-5.
|
| [4] | westm,sutherlandde,matasaj.kidneytransplantrecipientswhodiewithfunctioninggrafts:serumcreatininelevelandcauseofdeath[j].transplantation,1996,62(7):1029-30.
|
| [5] | 齐隽,闵志廉,朱有华,等.肾移植术后存活影响因素分析[j].中华外科杂志,2002,40(4):241-5.qij,minzl,zhuyh,etal.cadaverrenaltransplantationandmultivariateanalysisforgraftsurvival:aclinicalreviewof2016cases[j].chinjsurg,2002,40(4):241-5.
|
| [6] | 李留洋,胡丽娟,李民,等.肾移植后人类白细胞抗原抗体检测的临床意义[j].中华检验医学杂志,2002,25(1):324.lily,hulj,lim,etal.detectionofanti-hlaantibodiesanditsclinicalimplicationafterkidneytransplantation[j].chinjlabmed,2002,25(1):32-4.
|
| [7] | el-awarn,terasakip,lazdav,etal.almostallpatientswhoarewaitingforregraftofakidneytransplantationhaveanti-hlaantibodies[j].transplantproc,2002,34(7):2531-2.
|
| [8] | crespom,delmonicofl,saidmansl,etal.acutehumoralrejectioninkidneytransplantation[j].graft,2000,3(1):12-7.
|
| [9] | halloranpf,wadgymara,ritchies,etal.thesignificanceofanti-classⅰantibodyresponse.clinicalandpathologicfeaturesofanti-classⅰmediatedrejection[j].transplantation,1990,49(1):85-91.
|
| [10] | abem,kawait,futatsuyamak,etal.postoperativeproductionofanti-donorantibodyandchronicrejectioninrenaltransplantation[j].transplantation,1997,63(11):1616-9.
|
| [11] | sayeghmh.whydowerejectagraft?roleofindirectallo-recognitioningraftrejection[j].kidneyint,1999,56(5):1967-79.
|
| [12] | susalc,opelzg.kidneygraftfailureandpresensitizationagainsthlaclassⅰandclassⅱantigens[j].transplantation,2002,73(8):1269-73
|
| [13] | bryancf,shieldcf,piercege,etal.successfulcadavericrenaltransplantationofpatientshighlysensitizedtohlaclassⅰantigens[j].clintransplant,2000,14(1):79-84.
|
| [14] | 李留洋,岳良升,赵明.高致敏肾移植供受者的hla配型研究[j].中华泌尿外科杂志,2000,21(12):721-3.lily,yuels,zhaom.astudyofhlamatchingindonorsandhighlysensitizedrecipientsofrenaltransplantation[j].chinjurol,2000,21(12):721-3.
|
| [15] | wheelerdc,steigerj.evolutionandetiologyofcardiovasculardiseasesinrenaltransplantrecipients[j].transplantation,2000,70(suppl):s41-5.
|
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