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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂改善2型糖尿病合并动脉粥样硬化患者血管内皮功能近期疗效的对比研究
, PP. 967-971
Keywords: 血管紧张素转换酶抑制剂,血管紧张素受体拮抗剂,雷米普利,伊贝沙坦,内皮功能
Abstract:
目的比较血管紧张素转换酶抑制剂(acei)雷米普利5mg和血管紧张素受体拮抗剂(arb)伊贝沙坦150mg治疗2型糖尿病合并动脉粥样硬化(as)患者的肱动脉内皮功能的变化。方法确诊的2型糖尿病合并as患者用完全随机开放非均衡设计,将患者分为acei组99例,雷米普利开始剂量2.5mg/d,逐渐加至5mg/d;arb组25例,用伊贝沙坦逐渐加量至150mg/d;对照组21例,不用以上药物。疗程3个月以上。血管b超检查患者治疗前后肱动脉内皮功能的变化。随访3个月。结果与结论acei组患者治疗后肱动脉内皮依赖性舒张功能(edv)从(3.55±2.80)%提高至(5.62±4.18)%(p=0.001),肱动脉非内皮依赖性舒张功能(gtn)从(12.62±7.48)%提高至(12.80±7.04)%(p=0.835);arb组患者治疗后edv从(4.42±2.95)%提高到(6.28±3.26)%(p=0.039),gtn从(10.69±5.85)μg/l下降到(9.54±4.78)%(p=0.229)。而对照组患者治疗前后edv、gtn改变统计学差异不显著(p>0.05)。治疗前后edv、gtn变化值比较,acei组和arb组相比差异无统计学意义(p>0.05)。雷米普利5mg和伊贝沙坦150mg治疗2型糖尿病合并as患者3个月改善血管内皮功能差异无显著性。
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