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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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沙利度胺治疗肝癌的实验研究
, PP. 925-928
Keywords: 沙利度胺,肝癌,实体型,腹水型,阿霉素
Abstract:
目的研究沙利度胺对肝癌的治疗作用。方法采用小鼠肝癌移植性模型,观察沙利度胺对实体型和腹水型肿瘤的治疗作用。结果沙利度胺按每日200mg/kg连续给药10d,能明显抑制肝癌实体型肿瘤的生长,不降低小鼠血细胞数及淋巴细胞增殖;对腹水型肿瘤小鼠虽无明显生命延长作用,但沙利度胺与阿霉素联合用药对肝癌实体型及腹水型均有协调抗肿瘤作用,且可阻止阿霉素造成的小鼠血细胞减少、免疫功能降低。沙利度胺日剂量200mg/kg能明显增加肿瘤组织坏死,促进肿瘤组织边缘淋巴细胞侵润。结论沙利度胺对小鼠肝癌有确切治疗作用,与阿霉素联合用药效果更好。
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