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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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载硫化氢气体超声微泡的制备及其性能评价
Keywords: 微泡,超声,硫化氢
Abstract:
目的制备一种新型的载硫化氢气体的脂质微泡（hsmb）并评价其理化特性和超声显影能力。方法硫化氢和全氟丙烷按4∶0、3∶1、2∶2、1∶3和0∶4混合后，机械震荡法制备5种载相应混合气体的hsmb，即hsmb4∶0、hsmb3∶1、hsmb2∶2、hsmb1∶3和hsmb0∶4。检测微泡的粒径及浓度并评价其稳定性，优化气体混合比例。选取优化的混合气体制备的hsmb，观察超声辐照对微泡浓度及下清液中硫化氢浓度的影响；观察大鼠心肌及肾脏的超声显影效果。结果hsmb外观呈乳白色，镜下呈球形结构，无聚集现象。hsmb4∶0和hsmb3∶1微泡初始浓度较hsmb2∶2明显减少（p<0.05），且均随时间的延长逐渐降低。hsmb2∶2、hsmb1∶3和hsmb0∶4微泡初始浓度无差别（p>0.05），72h内浓度无变化（p>0.05）。超声辐照后，hsmb2∶2微泡浓度显著减少（p<0.05），而下清液中的硫化氢浓度明显增加（p<0.05）。hsmb2∶2静脉注射后获得良好的心脏及肾脏超声显影效果。结论硫化氢和全氟丙烷以2∶2混合制备的hsmb浓度高、稳定性良好，可在超声辐照下释放硫化氢，具有良好的超声显像效果，有望实现硫化氢气体可视化靶向传输。
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