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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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89srcl2治疗肺癌骨转移126例疗效分析
, PP. 1194-1196
Keywords: 锶放射性同位素/治疗应用,内照射治疗,肺肿瘤,骨肿瘤
Abstract:
目的探讨89srcl2治疗肺癌骨转移的疗效。方法不同病理类型肺癌骨转移患者126例,按148mbq/人次确定给药剂量,89srcl2由肘静脉一次性注射。以疼痛程度、疼痛频率及疼痛得分的变化衡量止痛效果,以病灶数目或大小的变化判断病灶疗效,比较不同病理类型肺癌疗效差异。结果治疗后6个月内,疼痛减轻率为70.6%(89/126),其中消失率为19.8%(25/126),表明疼痛程度明显缓解(u=5.361,p<0.01);78.6%(99/126)的患者疼痛频率下降,疼痛次数明显减少(u=4.589,p<0.01),其中25例疼痛不再发作。疼痛评分由7.54±3.29降低至4.19±4.38,降低显著(t=6.865,p<0.001)。病灶数目或大小减少25%以上者占45.2%(57/126)。89srcl2对鳞癌疼痛程度、频率缓解分别为85.7%(30/35)和88.6%(31/35),病灶改善率为57.1%(20/35)。各指标在4种肿瘤类型之间均无显著性差异(p>0.05)。结论89srcl2对肺癌骨转移的疗效较好,可缓解疼痛,改善病灶;89srcl2对不同病理类型肺癌骨转移疗效无明显差异。
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