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OALib Journal期刊
ISSN: 2333-9721
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胰酶在创伤/失血性休克后肠损伤中的作用
, PP. 1137-1139
Keywords: 休克,创伤性,休克,失血性,胰酶,肠损伤
Abstract:
目的通过观察胰蛋白酶抑制剂angd的作用,分析胰酶与创伤/失血性休克(t/hs)后肠损伤的关系。方法雄性sd大鼠剖腹术(创伤)后分别经肠腔或静脉内给予angd或生理盐水,随后经受t/hs或创伤/假休克(t/ss),90min后林格液复苏;复苏后3h评估肠损伤情况。结果肠腔内给予angd的t/hs大鼠肠绒毛损伤明显少于肠腔内无angd灌注及静脉给予angd的t/hs对照组。肠腔内灌注林格氏液与不行肠腔内灌注相比,对t/hs所致的肠损伤显示出某种程度的保护作用。结论肠腔内的胰蛋白酶可能是t/hs后肠损伤的重要促进因素。
| [1] | deitchea.multipleorganfailure:pathophysiologyandpotentialfuturetherapy[j].annsurg,1992,216(2):117-34.
|
| [2] | kistlereb,huglite,schmid-schonbeingw.thepancreasasasourceofcardiovascularcellactivatingfactors[j].microcirculation,2000,7(3):183-92.
|
| [3] | kyogokut,manabet,tobet.roleofischemiainacutepancreatitis.hemorrhagicshockconvertsedematouspancreatitistohemorrhagicpancreatitisinrats[j].digdissci,1992,37(9):1409-17.
|
| [4] | sakorafasgh,tsiotosgg,sarrmg.ischemia/reperfusion-inducedpancreatitis[j].digsurg,2000,17(1):3-14.
|
| [5] | ramachandrana,balasubramanianka.proteaseactivationduringsurgicalstressinratsmallintestine[j].jsurgres,2000,92(2):283-90.
|
| [6] | leferam,spathjajr.pancreatichypoperfusionandtheproductionofamyocardialdepressantfactorinhemorrhagicshock[j].annsurg,1974,179(6):868-76.
|
| [7] | montgomerya,borgstroma,haglundu.pancreaticproteasesandintestinalmucosalinjuryafterischemiaandreperfusioninthepig[j].gastroenterology,1992,102(1):216-22.
|
| [8] | aoyamat,inoy,ozekim,etal.pharmacologicalstudiesoffut-175,nafamstatmesilate.i.inhibitionofproteaseactivityininvitroandinvivoexperiment[j].jpnjpharmacol,1984,35(3):203-27.
|
| [9] | schmid-schonbeingw,kistlereb,huglite.mechanismsforcellactivationanditsconsequencesforbiorheologyandmicrocir:culation:multi-organfailureinshock[j].biorheology,2001,38(2-3):185-201.
|
| [10] | shihp,deitchea,xudz,etal.hypertonicsalineimprovesintestinalmucosabarrierfunctionandlunginjuryaftertraumahemorrhagicshock[j].shock,2002,17(6):496-501.
|
| [11] | leferam,glenntm.roleofthepancreasinthepathogenesisofcirculatoryshock[j].advexpmedbiol,1971,23:311-35.
|
| [12] | glenntm,herlihybl,fergusonww,etal.protectiveeffectofpancreaticductligationinsplanchnicischemiashock[j].amjphysiol,1972,222(5):1278-84.
|
| [13] | jonesrt,garciajh,mergnerwj,etal.effectsofshockonthepancreaticacinarcell.cellularandsubcellulareffectsinhumans[j].archpathol,1975,99(12):634-44.
|
| [14] | bounousg,brownra,mulderds,etal.abolitionof＂trypticenteritis＂intheshockeddog[j].archsurg,1965,91:371-5.
|
| [15] | deitchea,shihp,luq,etal.serineproteasesareinvolvedinthepathogenesisoftrauma-hemorrhagicshock-inducedgutandlunginjury[j].shock,2003,19(5):452-6.
|
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