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OALib Journal期刊
ISSN: 2333-9721
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豚鼠胆固醇结石形成中胃肠移行性复合波与胆酸池大小的变化
Keywords: 胆固醇结石,胆酸肠肝循环,胆酸池,胃肠移行性复合波,胆囊动力
Abstract:
目的研究豚鼠在胆固醇结石形成中胃肠移行性复合波(mmc)与胆酸池大小的变化。方法75只豚鼠分别给予正常饮食8周,1%胆固醇饮食2、4、8周,胆固醇加维生素c饮食8周。喂养结束后,评估胆囊动力并将4对电极植入胃窦、十二指肠、空肠、回肠。7d后,记录mmc并测量胆酸池大小。结果胆固醇喂养后,胆囊动力在4周与8周组下降。胆酸池在4周组减小42.75%(p<0.05),8周组减小57.24%(p<0.05)。与对照组相比,mmc以十二指肠起源为主,周期延长(4周组1.32倍,p<0.05;8周组1.44倍,p<0.05),而波幅降低(4周组降低40.91%,p<0.05;8周组降低60.17%,p<0.05)。加维生素c引起的变化与胆固醇喂养的2周组相似。结论高胆固醇饮食抑制mmc并减小胆酸池,与损伤的胆囊动力一起导致胆固醇结石形成。
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