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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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l-型钙通道α1亚单位在成年鼠海马神经元上的差异性表达
, PP. 1225-1227
Keywords: 海马,神经元,l-型钙通道亚单位,差异性表达,免疫组织化学
Abstract:
目的观察l-型钙通道不同的α1亚单位在成年鼠海马不同亚区神经元中表达的变化。方法运用免疫组织化学染色方法特异性地标记脑型l-型l-型钙通道不同的α1亚单位cav1.2α1c和cav1.3α1d。结果cav1.2α1c主要分布在ca1区锥体细胞突起部分及ca3区锥体细胞的胞体区、基树突和远端顶树突;cav1.3α1d则主要集中分布在海马各亚区的胞体区和近端突起;此外,cav1.2α1c和cav1.3α1d在细胞局部的分布特性上亦明显不同,前者主要呈现簇状分布,而后者则呈均匀分布。结论l-型钙通道cav1.2α1c和cav1.3α1d亚单位在成年鼠海马不同亚区神经元中呈现差异性表达。
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